Coversyl Plus 5Mg/1.25Mg Tablet
Description : Each film-coated tablet contains perindopril 5 or 10 mg and indapamide 1.25 or 2.5 mg.
Indications / Uses : Essential HTN.
Administration : Should be taken on an empty stomach: Take before meals.
Contraindications : Hypersensitivity to perindopril or any other ACE inhibitors, indapamide or any other sulfonamide. Angioedema, severe hepatic disease or encephalopathy, severe kidney disease or in renal disease w/ dialysis, low or high blood K, decompensated heart failure. Pregnancy & lactation. Childn.
Special Precautions : Aortic stenosis, hypertrophic cardiomyopathy or renal artery stenosis, other heart problems. Renal or hepatic impairment, SLE or scleroderma, atherosclerosis, hyperparathyroidism, gout, diabetes (monitor blood glucose particularly in the presence of hypokalemia). Patients undergoing anesth &/or surgery, diarrhea, vomiting, dehydration, LDL apheresis, desensitization treatment, medical test that requires inj of iodinated contrast agent, salt-restricted diet. May give +ve reaction in drug tests. Contains lactose. Perindopril in patients w/ collagen vascular disease, immunosuppressant therapy, treatment w/ allopurinol or procainamide, or a combination of these complicating factors especially if there is preexisting impaired renal function [some may develop serious infections which in a few instances did not respond to intensive antibiotic therapy; periodical monitoring of WBC count is advised & patients should report any sign of infection (eg, sore throat, fever)]. Measure plasma Na before starting treatment, then at regular intervals (any diuretic treatment may cause hyponatremia, sometimes w/ very serious consequences; frequent monitoring in elderly & cirrhotic patients. Prevent risk of onset of hypokalemia (<3.4 mmol/L) by frequent monitoring of plasma K in high risk populations ie, the elderly, malnourished &/or polymedicated, cirrhotic w/ edema & ascites, CAD & cardiac failure (obtain 1st measurement of plasma K during 1st wk following start of treatment; detection of hypokalemia requires its correction). Renal function & K levels should be tested before the start of treatment. Elderly.