ZYNAPSE 500MG CAPSULE
Indications / Uses :
Cerebrovascular Diseases (eg, from Ischemia due to Stroke): Citicoline accelerates the recovery of consciousness and overcoming motor deficit. The clinical testing of citicoline has challenged the historical concept that one can do nothing for a stroke patient after a certain period of time has transpired after the onset of symptoms. The practicality of a drug that can be administered up to 24 hrs after stroke is a key factor in evaluating the potential of citicoline.
The results of a recent phase 3 clinical trial among patients suffering from ischemic stroke demonstrated a statistically and clinically significant improvement in the neurological function of patients treated with optimal dose of citicoline 500 mg daily. The potential of citicoline as stroke therapy is underscored by other key attributes: Its oral dosage for a 24-hr window of therapeutic opportunity following stroke and an apparent absence of significant side effects. Preliminary evidence suggests that in a small subgroup of patients, citicoline may reduce the size of the impact caused by stroke.
Treatment of citicoline within the first 24 hrs after onset in patients with moderate to severe stroke increase the probability of complete recovery at 3 months.
Head Trauma of Varying Severity: In a clinical trial, citicoline accelerated the recovery from posttraumatic coma and the recuperation of walking ability, achieved a better final functional result and reduced hospital stay.
Cognitive Disorders of Diverse Etiology [eg, Senile Cognitive Impairment which is Secondary to Degenerative Diseases (eg, Alzheimer’s disease) and to Chronic Cerebral Vascular Disease]: Citicoline improves scores on cognitive evaluation scales and slowed the progression of Alzheimer’s disease.
Parkinson’s Disease: Citicoline has also been shown to be effective as co-therapy for Parkinson’s disease. Beneficial neuroendocrine, neuroimmunomodulatory and neurophysiological effects have been described. Considerable experimental evidence of effects of citicoline on CNS dopaminergic system has accumulated. After treatment with citicoline, regeneration of cells in rats with substantia nigra lesions has been demonstrated. Citicoline increases striataldopamine and tyrosine hydroxylase synthesis.
Patients with hypertonia of the parasympathetic.
Special Precautions :
Use in pregnancy & lactation: There is inadequate evidence of safe use of Zynapse in human pregnancy. Zynapse should be used in pregnancy and lactation only if the potential benefits justify the potential risks.
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