Capsule: Each capsule contains pizotifen 500 mcg, vitamin B1 3.0 mg, vitamin B2 3.2 mg, vitamin B6 2.4 mg and nicotinamide 19.0 mg.
Syrup: Each 5 mL syrup contains pizotifen 250 mcg, vitamin B1 700 mcg, vitamin B2 1.14 mg, vitamin B6 700 mcg and nicotinamide 5 mg.
Indications / Uses :
Anorexia of somatic or psychogenic origin in underweight patients, supplementary to the treatment of the underlying condition, such as infectious or parasitic diseases (including convalescence), chronic diarrhea, anorexia nervosa or depressive states in the elderly; Depressive mood in the elderly.
May be taken with or without food: May be taken w/ meals if GI discomfort occurs.
Known hypersensitivity to pizotifen or any of the excipients.
Appetens should not be given to children under 2 years of age.
Special Precautions :
In view of the slight anticholinergic effect of pizotifen, caution is required in patients with narrow-angle glaucoma (except those successfully treated by surgery) or urinary retention (e.g. in prostatic enlargement). Up to now, no untoward reactions have been reported in such patients, not even in the elderly, when given the recommended dose. Appetens increase appetite and may lead to an increase in body weight. However, weight gain is dependent on adequate food intake, and anorexia must be differentiated from malnutrition.
Effects on the Ability to Drive and Use Machines: Patients should be warned that, owing to its possible sedative effect, Appetens may slow their reactions when driving vehicle, operating machinery, etc