Godex: Each capsule contains carnitine orotate 150 mg, 17 amino acids 12.5 mg, pyridoxine HCl (vit B6) 25 mg, adenine HCl 2.5 mg, cyanocobalamin (vit B12) 125 mcg and riboflavin (vit B2) 500 mcg.
Godex preparation has been developed by a Spanish pharmaceutical company as ethical therapeutics for mitochondrial dysfunctions.
Carnitine orotate represents functional histological restoration effect to injured hepatocytes and also acts as lipotropic factor to fatty liver. It promotes ?-oxidation of normal free fatty acids and metabolism in hepatocytic mitochondria.
Hepatic (liver) extract antitoxic fraction (purified detoxicable liver extract hydrolysate) represents highly activated detoxification effect on intrinsic and extrinsic hepatotoxic substances. Based on clinical studies, it has excellent therapeutic results with marked improvement on many kinds of functional histological profiles [ie, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), bilirubin, biopsy] and vital signs (ie, weight loss, nausea).
Godex DS: Each capsule contains carnitine orotate 300 mg, 17 amino acid 25 mg, adenine hydrochloride 5 mg, pyridoxine hydrochloride (vitamin B6) 50 mg, riboflavin (vitamin B2) 1 mg and cyanocobalamin (vitamin B12) 250 mcg.
Pyrimidine nucleotide precursor, orotate, combined with pharmaceutically acceptable salts cationic carnitine, carnitine HCl, 17 amino acids and more agents (adenosine, pyridoxine HCl, cyanocobalamin) with protective or supportive activity relative to mitochondrial structure and function.
Carnitine Orotate, the molecular formula is C7H16NO3C5H3N2O4:C12H19N3O7; the molecular weight is 333.34 g/mol, which when administered in vivo has a synergistic effect. It increases solubility and is more easily absorbed by the injured cells, rather than the administration of carnitine individually.
Cyanocobalamin (vitamin B12) is 5,6-dimethyl-benzimidazolyl cyanocobamide; molecular formula is C63H88 C0N14O14P. The cobalt content is 4.34%. The molecular weight is 1355.39. Vitamin B12 is bound to intrinsic factor during transit through the stomach; separation occurs in the terminal ileum in the presence of calcium and vitamin B12 enters the mucosal cell for absorption. It is then transported by the transcobalamin binding proteins.
Indications / Uses :
Treatment of mitochondrial dysfunctions, acute and chronic viral hepatitis, fatty liver, drug-induced liver injury, cirrhosis, alcoholic and general intoxication.
May be taken with or without food.
Godex DS: Hypersensitivity to any of the components of Godex DS. Severe renal dysfunction (serum creatinine >3 mg/100 mL).
Special Precautions :
Administration of doses of cyanocobalamin >10 mcg daily may produce a hematological response in patients with folate deficiency; indiscriminate use may mask the precise diagnosis.
Godex DS: Long-term use of large doses of pyridoxine is associated with the development of severe peripheral neuropathies.