HUMAMET 850MG CAPSULE
Metformin HCl is an oral antihyperglycemic drug. Metformin HCl is N, N-dimethylimidodicarbonimidic diamide hydrochloride chemically. It is a white to off-white crystalline powder. It is freely soluble in water and is practically insoluble in acetone, chloroform and ether. Its molecular formula is C4H11N5?HCl.
Indications / Uses :
Humamet: To improve glycemic control in patients with non-insulin dependent diabetes mellitus (NIDDM) where there is poor diet control; primary and secondary failures to sulfonylurea treatment and those having a trend for increasing the body weight; diabetic with an exceeding body weight.
Humamet can be given alone as an initial treatment or to supplement treatment with a sulfonylurea. In patients with insulin-dependent diabetes mellitus (type I) who are not adequately controlled, Humamet can be added to their existing treatment regimen.
Should be taken with food: Swallow whole, do not chew/crush.
Hypersensitivity to metformin HCl or to any of the excipients of Humamet/Humamet XR 500.
Humamet: Patients with the following conditions: Renal disease or dysfunction, chronic liver disease, cardiac failure, recent myocardial infarction; acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without coma. Diabetic ketoacidosis should be treated with insulin. History of, or states associated with lactic acidosis or hypoxemia, alcoholism.
The use of Humamet should be stopped 2-3 days before surgery or clinical investigations eg, IV urography and IV angiography. It should be resumed only after control of renal function has been regained.
Special Precautions :
Humamet: Humamet is known to be excreted in the kidney thus, patients with impaired renal function should be caution. Regular monitoring of renal function is advisable in all diabetic patients. The use of Humamet is not advised in conditions which may cause dehydration or in patients suffering from serious infections or trauma.
Patients receiving Humamet should have their vitamin B12 levels estimated annually since decreased vitamin B12 absorption has been reported.
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