Neo-Penotran Vag Supp
Neo-Penotran: Each vaginal suppository contains metronidazole 500 mg and miconazole nitrate 100 mg.
Neo-Penotran Forte: Each vaginal suppository contains metronidazole 750 mg and miconazole nitrate 200 mg.
Neo-Penotran Forte-L: Each vaginal suppository contains metronidazole 750 mg, miconazole nitrate 200 mg and lidocaine 100 mg.
Indications / Uses :
Treatment of vaginal candidiasis caused by Candida albicans, bacterial vaginitis caused by anaerobic bacteria and Gardnerella vaginalis, trichomonal vaginitis caused by Trichomonas vaginalis and mixed vaginal infections.
Known hypersensitivity to any active ingredients or derivatives of Neo-Penotran/Neo-Penotran Forte/Neo-Penotran Forte-L. Patients with severe liver function disorders (including porphyria), nervous system disoders (eg, epilepsy) and hematopoiesis.
Special Precautions :
Patients should be warned not to take alcohol during the therapy and for at least 2 days after the end of a course of treatment because of the possibility of disulfiram-like reactions.
High doses and long-term systemic use may cause peripheral neuropathy and convulsion.
The base contained in the vaginal suppository formulation may interact with certain rubber or latex products eg, those used in vaginal contraceptive diaphragms or condoms, therefore concurrent use is not recommended.
Sexual partners of patients with Trichomonas vaginalis should be treated at the same time.
Metronidazole dose must be reduced in renal failure.
In serious liver function failures, metronidazole clearance may be impaired. Metronidazole may increase encephalopathy symptoms due to increased plasma levels and therefore should be used carefully in hepatic encephalopathy patients. The daily dose of metronidazole must be reduced to ? in patients with hepatic encephalopathy. The t? of lidocaine may be prolonged =2-folds in patients with impaired liver function. Impaired renal function does not affect the pharmacokinetics of lidocaine but may increase accumulation of metabolites.
Neo-Penotran/Neo-Penotran Forte/Neo-Penotran Forte L is not recommended for use in virgins.