NORPLAT 75MG TABLET
Description : Norplat is an inhibitor of ADP-induced platelet aggregation. It reduces the chance of having a heart attack or a stroke in people who have already had a heart attack or a stroke.
Clopidogrel bisulfate is methyl (+)-(S)-a-(2-chlorophenyl)-6-7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate sulfate (1:1). Its molecular formula is C16H16ClNO2S?H2SO4.
Norplat-S: Each enteric-coated tablet contains clopidogrel bisulfate 75 mg and aspirin 75 mg.
Norplat-S is a fixed-dose combination containing clopidogrel and aspirin.
Aspirin, also an antiplatelet agent, is 2-(acetyloxy) benzoic acid. Its molecular formula is C9H8O4.
Indications / Uses : Norplat Prevention of atherosclerotic events in peripheral arterial disease or w/in 35 days of MI or w/in 6 mth of ischemic stroke, or in active coronary syndrome w/o ST-segment elevation. Norplat-S Prevention of ischemic events, MI, stroke & CV death in patients w/ acute coronary syndrome.
Administration : May be taken with or without food.
Contraindications : Norplat Patients who suffer from active pathological bleeding eg, peptic ulcer or intracranial hemorrhage. Norplat-S Hypersensitivity to salicylates (bronchospasm, anaphylactic reactions). Active gastroduodenal ulcers, hemorrhagic disease, severe hepatic impairment. Pregnancy & lactation.
Special Precautions : Norplat Patients who have lesions w/ a propensity to bleed eg, ulcers, renal & hepatic impairment, at risk of increased bleeding from trauma, surgery or other pathological conditions or to undergo elective surgery. Hematopoietic disorders eg, neutropenia or thrombocytopenia, hemorrhagic diathesis or other hemorrhagic disorders. Pregnancy & lactation. Childn. Norplat-S Perform full blood count prior to treatment, every 2 wk during 1st 3 mth of therapy & w/in 2 wk of discontinuing treatment. Allergy to ibuprofen or other NSAIDs; chronic or recurrent stomach or duodenal ulcers or digestive hemorrhages; severe renal impairment/disease & hepatic disease; allergic diseases eg, asthma or urticaria; gout. Patients at increased risk of bleeding from trauma, surgery or other pathological conditions. Discontinue use 5 days prior to elective surgery. Lesions which has a propensity to bleed eg, ulcers. Concomitant use w/ drugs that can induce lesions. Childn & adolescents w/ chickenpox, flu or fever.