VASCORIDE 10MG TABLET
Indications / Uses : Treatment of hypertension.
Administration : May be taken with or without food.
Contraindications : Known hypersensitivity to any of the components of Vascoride. Sulfonamide hypersensitivity or thiazide diuretic hypersensitivity because of the risk of cross-sensitivity.
History of angioneurotic edema.
Renal failure and anuria since thiazide diuretics are considered ineffective when the CrCl <30 mL/min.
Special Precautions : Use with caution in patients with the following conditions:
Sodium depletion or hypovolemia, and those undergoing dialysis, major surgery or during anesthesia since severe hypotension may occur.
Renal disease, especially among elderly patients. Old age and impaired renal function may decrease the urinary excretion of imidapril and its metabolites. Hydrochlorothiazide may also decrease glomerular filtration rate and may precipitate azotemia in these patients.
Unilateral or bilateral artery stenosis since increase in BUN and serum creatinine may occur.
Renal dysfunction that is critically dependent on the activity of the renin-angiotensin-aldosterone system (RAS) (eg, patients with heart failure) since angiotensin-II receptor antagonists affect the RAS system and have caused increases in serum creatinine and renal failure in susceptible individuals.
Hepatic disease since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Gout or hyperuricemia since thiazide diuretics eg, hydrochlorothiazide have been reported to reduce the clearance of uric acid.
History of pancreatitis since thiazide diuretics have been reported to cause pancreatitis.