Duavent P-Neb 500Mcg
Indications / Uses :
Management of reversible bronchospasm associated with obstructive airway diseases (eg, bronchial asthma).
For patients with chronic obstructive pulmonary disease (COPD) on a regular inhaled bronchodilator who continue to have evidence of bronchospasm and who require a second bronchodilator.
Hypersensitivity to soya lecithin or related food products eg, soybeans or peanuts; and to any component of Duavent or to atropine and its derivatives. Hypertrophic obstructive cardiomyopathy or tachyarrhythmia.
Special Precautions :
Patients should avoid spraying the aerosol into the eyes since this may result in precipitation or worsening of narrow-angle glaucoma, eye pain or discomfort, temporary blurring of vision, visual halos or colored images in association of red eyes from conjunctival and corneal congestion. Consult a physician if any combination of these symptoms develops. Use with caution in patients with the following conditions: Prostatic hypertrophy or bladder-neck obstruction; convulsive disorders, hyperthyroidism or diabetes mellitus and in patients who are unusually responsive to sympathomimetic amines (?-adrenergic agents may also produce significant hypokalemia in some patients, possibly through intracellular shunting, which has the potential to produce adverse cardiovascular effects. The decrease in serum potassium is usually transient, not requiring supplementation.); hepatic or renal disease, since use of Duavent in these patients has not been studied.
Use in pregnancy & lactation: Safety and efficacy of Duavent during pregnancy has not yet been established. The inhibitory effect of Duavent on uterine contraction should be taken into account.
It is not known whether the components (ipratropium bromide and salbutamol sulfate) of the FDC are excreted in human milk. Although lipid-insoluble quaternary bases pass into breast milk, it is unlikely that ipratropium bromide would reach the infant to an important extent, especially when taken as a nebulized solution. Because of the potential for tumorigenicity shown for salbutamol sulfate in some animals, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Labor and Delivery: Since ?2-agonists may interfere with uterine contraction, Duavent should be used in labor only if the potential benefit justifies the potential risk.
Use in children: The safety and efficacy of the FDC in patients <18 years have not been established.