Nidcor 500 Mg Tablet
Each film coated tablet contains metformin hydrochloride 500 mg.
Indications / Uses :
To improve glycemic control in patients with type II (non-insulin dependent diabetes mellitus). It may be given alone as an initial treatment or concomitantly with a sulfonylurea and/or insulin.
Should be taken with food: Gradually increase dose to reduce GI effects/discomfort.
Metformin is contraindicated in patients with: Known hypersensitivity to metformin; renal disease or renal impairment; liver disease and chronic hypoxic lung disease; heart failure requiring pharmacologic treatment; history of lactic acidosis.
Special Precautions :
Metformin should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast media, because use of such products may result in acute renal dysfunction.
Patients with renal impairment should not be given metformin. In patients with advanced age, metformin should be carefully titrated to establish the minimum dose for adequate glycemic effect, because aging is associated with reduced renal function. In those at least 80 years of age, renal function should be monitored regularly.
Alcohol is known to potentiate the effect of metformin on lactate metabolism.
Metformin should be avoided in patients with evidence of hepatic disease, since impaired hepatic function has been associated with lactic acidosis.
Metformin is not recommended for use in pregnancy and in pediatric patients. Dosage of metformin should be titrated in patients with advanced age. Elderly, debilitated and malnourished patients should not be given to the maximum dose. Monitoring of renal function is necessary to prevent lactic acidosis, particularly in the elderly.