TAPAZOLE 20MG TABLET
Description : Methimazole, 1-methyl-imidazole-2-thiol, is a white, crystalline substance that is freely soluble in water. It differs chemically from the drugs of the thiouracil series primarily because it has a 5- instead of a 6-membered ring. The molecular weight is 114.16 and the empirical formula is C4H6N2S. It is an orally administered antithyroid drug.
Indications / Uses : Treatment of hyperthyroidism. May be used to ameliorate hyperthyroidism in prep for subtotal thyroidectomy or radioactive iodine therapy. Used when thyroidectomy is contraindicated or not advisable.
Administration : Should be taken with food.
Contraindications : Hypersensitivity. Lactation.
Special Precautions : Long-term therapy may lead to remission of the disease. Discontinue use in the presence of agranulocytosis (symptoms include fever, sore throat, skin eruptions, headache or general malaise), aplastic anemia (pancytopenia), hepatitis, exfoliative dermatitis; hepatic transaminase >3 times ULN. Monitor prothrombin time esp before surgical procedures; bone marrow, liver & thyroid function periodically. Concomitant use w/ drugs known to cause agranulocytosis. Pregnancy.